Supporting Online Material: Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum
نویسندگان
چکیده
Department of Cellular and Molecular Pharmacology, Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California San Francisco, California Institute for Quantitative Biomedical Research, San Francisco, CA 94143, USA. Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom. Present address: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Present address: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
منابع مشابه
Martin C . Jonikas , for Protein Folding in the Endoplasmic Reticulum Comprehensive Characterization of Genes Required
www.sciencemag.org (this information is current as of July 31, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/323/5922/1693 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/323/5922/1693/DC1 can be found...
متن کاملZanthoxylum Alatum Attenuates Chronic Restraint Stress Adverse Behavioral Effects Via the Mitigation of Oxidative Stress and Modulating the Expression of Genes Involved in Endoplasmic Reticulum Stress in Mice
Introduction: The functions of the endoplasmic reticulum (ER) are important, particularly in the proteins’ synthesis, folding, modification, and transport. Based on traditional medicine and our previous studies on Zanthoxylum alatum in lipopolysaccharide-induced depressive behavior and scopolamine-induced impaired memory, the present study explored the role of hydroalcoholic extract of Z. alatu...
متن کاملComprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein response), we identified several hundred yeast genes with roles in endoplasmic reticulum folding and systematically characterized their functional interdependencies by measuring unfolded protein response levels in dou...
متن کاملGating Behavior of Endoplasmic Reticulum Potassium Channels of Rat Hepatocytes in Diabetes
Background: Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic...
متن کاملAllantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions
Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective. Allantoin is one of the principal compounds in many plants and an imidazoline I receptor agonist as well. Allantoin has positive eff...
متن کامل